Since we're already out here using exogenous hormones to hit our physique goals, it feels like we should be looking into hormones that can actually help with longevity too. From what I've seen, 17-alpha-estradiol is looking like one of the most promising interventions for extending the lifespan of male mice.
It's one of the few things that consistently shows benefits in the ITP studies. The best part is that it's supposedly non-feminizing, so there's basically zero risk of catching a case of gyno from it.
I’ve been thinking it would be interesting to see if we could use this stuff to offset the side effects of having low 17-beta-estradiol. Like, imagine keeping your actual estrogen on the lower end with some Primo or an AI to keep the gyno risk at zero, but then "filling in the gaps" with the alpha variant to keep the health benefits. I’m not sure if that’s actually doable though- maybe the "good" parts of estrogen are tied directly to the feminizing receptors and you can't have one without the other. I haven't been able to find much info on that specifically, but even if you can't swap them, it still seems like a great health ancillary.
Since I basically identify as a male mouse anyway, I'm curious if anyone here has actually ran 17-alpha-estradiol or has any theories on it?
The obvious issue is sourcing. If a vendor doesn't separate the isomers right and you get the wrong one, you're going to transition into a woman pretty fast lol. Just to be clear though- the 17-alpha version specifically is the one that isn't supposed to be feminizing.
ngl “male mouse” made me laugh but I get what you’re saying lol interesting thought
the longevity angle is cool but mice data always makes me cautious to extrapolate too hard
the idea of separating health benefits from feminizing effects sounds great on paper
feels like one of those things that’s way more complex once humans are involved
sourcing alone would sketch me out tbh- one tiny mistake and oops
also kinda wonder if estrogen’s benefits are tied to the same pathways you’re trying to avoid
“identify as a male mouse” had me laughing lol. but yeah the ITP data on 17a is actually pretty interesting, at least on paper
i’ve wondered the same thing about whether you can separate the health benefits from the feminizing effects or if that’s wishful thinking. biology usually isn’t that generous
i don’t know anyone who’s actually run it IRL. feels like one of those things that’s cool in mouse studies but sketchy once humans start experimenting
sourcing alone would scare me off tbh. one mixup and suddenly you’re learning a lot about bras and emotions real fast
i like the idea of thinking longevity alongside physique tho. most people only care about looking good right now and ignore the long game completely
