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Just pinned my first dose of Tirzepatide

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RustyCompass91
(@rustycompass91)
Posts: 5
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I took my very first shot of Tirz this past Monday. I decided to start super low at 1.25mg just to play it safe since I tend to be a hyper-responder to stuff like GH, and honestly, that’s just how I roll. I always try to find the absolute minimum dose that get the job done before I even think about moving up. Surprisingly, I think I’m actually feeling it already. It could totally be placebo, but on the first day I had zero appetite. By the second day, I felt a little hunger, but it went away as soon as I ate something. Today is day three and I'm definitely hungrier, but it's nothing I can't handle.

I’m currently running a pretty aggressive deficit-somewhere around 900 to 1100 calories below my maintenance. I’ll see how I feel by day seven, but I’ll probably stick with 1.25mg for one more week. If the appetite suppression isn't where I want it, I'll bump it to 2mg. So far, I've had zero issues with nausea, GERD, or anything else.

For reference, I’m also running 500mg Metformin ER twice a day, 1mg of Anastrozole split throughout the week, 200mg TRT, 2iu of GH every other day, 500iu of HCG, and 5mg of Rosuvastatin at night. I've got a few other meds in the mix too for different conditions, but that's the main stuff.

Would you like me to rewrite any other posts for you?


 
Posted : 22/01/2026 6:40 pm
just_a_tech
(@just_a_tech)
Posts: 4
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starting low is smart honestly. i wish i did that instead of jumping in and feeling wrecked week one


 
Posted : 22/01/2026 8:00 pm
2nd_Fermenter
(@2nd_fermenter)
Posts: 5
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sounds like it’s already doing something even at 1.25. placebo or not appetite going quiet is a win


 
Posted : 22/01/2026 8:01 pm
BlindingTru7h
(@blindingtru7h)
Posts: 5
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day 3 hunger coming back is pretty normal from what i’ve seen. week 2 is where it really settled in for me


 
Posted : 22/01/2026 8:01 pm
time_keepsonslipping
(@time_keepsonslipping)
Posts: 5
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zero sides is huge especially with that stack. nausea scared me off at first but never hit either


 
Posted : 22/01/2026 8:02 pm
femmeist
(@femmeist)
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900-1100 deficit is aggressive tho lol make sure energy doesn’t tank too hard


 
Posted : 22/01/2026 8:03 pm
Tuvinator
(@tuvinator)
Posts: 5
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i’m the same way with minimum effective dose. no reason to rush up if it’s working


 
Posted : 22/01/2026 8:04 pm
mylittlepoggie
(@mylittlepoggie)
Posts: 5
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the fact that hunger goes away once you eat is a good sign imo


 
Posted : 22/01/2026 8:05 pm
ApplesaurusFlexxx
(@applesaurusflexxx)
Posts: 8
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smart plan holding the dose another week. patience pays off with this stuff

 


 
Posted : 22/01/2026 8:06 pm
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