The E4 stuff is actually super interesting because it’s not just for preventing new scars—the data coming out of MUSC suggests it can actually reverse existing fibrosis by waking up the urokinase pathway to chew up old collagen. Last I heard, a company called iBio was pushing it through preclinical to get it ready for human safety trials, though it's been a slow burn.

i’ve seen people saying trials were supposed to move forward but it kinda went quiet which usually means funding or stability issues more than anything. happens a lot with peptides

the latest update is that a company called iBio is actually turning E4 into a more stable version called END55 (it's a fusion protein) and they’ve been pushing for phase 1 human trials lately. for m10 it is a similar vibe—it is a tiny 10 amino acid peptide that blocks the smad2 pathway which is what usually signals your body to start dumping collagen and creating scars.

especially looked crazy in those studies, actually reversing fibrosis in mice and even working on already established scar tissue which is kinda wild . but the catch is it never really made a clean jump into human data, or at least nothing public. i remember seeing talk that it might’ve been heading toward early trials years ago but then everything just went quiet.

Yeah I’ve seen both of these come up in the fibrosis research rabbit hole, and the short version is: they look very promising in preclinical work, but there’s basically no solid human data or active public clinical progress you can actually track.

the anti scarring angle sounds awesome honestly especially for people dealing with old injuries or surgeries. curious how far along these trials even are because info is hard to find