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Advice on the best way to run Retatrutide?

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TitaniumFalcon
(@titaniumfalcon)
Posts: 5
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I’m looking for some input on how to best set up a Retatrutide cycle. Right now, I’m sitting at 235 pounds and the goal is to drop about 25 pounds total. I’d really like to see at least three or four inches come off my waistline by the time I'm done.

My plan is to start with a 12-week run. I was thinking of staying at 2mg for a while and then slowly ramping the dose up-maybe hitting 3mg once I see how my body handles it. Does this sound like a solid approach to hit those goals, or should I be looking at a different dosing schedule? I'd appreciate any advice from guys who have already messed with this stuff.


 
Posted : 29/01/2026 6:56 pm
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Decent_Garden941
(@decent_garden941)
Posts: 13
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honestly 2mg is a great place to start with reta. it is way more potent than semaglutide or tirzepatide because of that third glucagon receptor so you really want to ease into it. if you jump too high too fast your heart rate might get a bit jumpy. 12 weeks is a solid timeframe but don't be surprised if the weight starts falling off faster than you expected!


 
Posted : 29/01/2026 7:51 pm
phillyin0v8r
(@phillyin0v8r)
Posts: 10
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reta is a total game changer man. i started at 2mg as well and the hunger suppression was insane compared to anything else ive tried. just a heads up - make sure you are still hitting your protein goals because it is easy to forget to eat entirely on this stuff and you dont want to lose all your hard earned muscle while you drop those 25 pounds.


 
Posted : 29/01/2026 7:51 pm
TeachingNo2517
(@teachingno2517)
Posts: 12
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man i wish i could find some legit reta right now lol. your plan to stay at 2mg for a while is smart. dont rush the titration because once you hit that "sweet spot" where the weight is dropping you should just stay there as long as possible. if 2mg is working there is no real reason to even go to 3mg yet.


 
Posted : 29/01/2026 7:52 pm
911__
(@911__)
Posts: 12
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3-4 inches off the waist is totally doable with reta. it has that glucagon kick that really targets the belly fat. just watch your hydration because i noticed i got dehydrated way faster on this stuff. at 235 you should see some pretty dramatic changes in those first 12 weeks if your diet is even halfway decent.


 
Posted : 29/01/2026 7:52 pm
chzformymac
(@chzformymac)
Posts: 11
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the 2mg to 3mg ramp is perfect. i tried jumping straight to 4mg after a month and i felt like i had a permanent shot of espresso in my veins lol. it definitely increases your resting heart rate a bit so just be aware of that. but for fat loss? nothing touches reta right now. it's basically cheating.


 
Posted : 29/01/2026 7:52 pm
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